Dr Robert W. Stackman         HomePage

Research Interests

  • Neurobiology of Learning and Memory
  • Spatial Navigation
  • Brain Representations of Space (i.e., place cells and head direction cells)
  • Mouse Models of Alzheimer's disease

My lab employs a systems level approach to investigate the brain mechanisms that underlie complex behaviors such as learning, memory and spatial navigation. We use multiple techniques, including neuropharmacological tools and electrophysiological methods, to examine how the brain stores and represents information. Our research focuses on the hippocampal formation, an essential brain structure for memory and navigation. The hippocampal formation is compromised by aging and Alzheimer's disease. One goal of this work is to identify mechanisms that might be useful targets for the development of novel treatments of age-related cognitive decline.

Research Areas

  • Neurobiology of learning & memory
  • spatial navigation

Current Projects

  1. Examination of the acute effects of alcohol on spatial navigation and the firing properties of hippocampal place cells and thalamic head direction cells (with support from the National Institutes of Health: NIAAA award #AA014407)
  2. Examination of the influences of small conductance calcium-activated potassium channels (SK channels) on hippocampal learning and memory (with support from the National Institutes of Health: NIMH award #MH086591) and the National Science Foundation: Integrative Organismal Biology award #0630522)
  3. Examination of the interactive influences of head direction cells and place cells on spatial navigation
  4. Testing the cognitive influences of the neurosteroid allopregnanolone.